Self defense bullet for 12.5" barrel for under 50 yards?

[Happy2Shoot]

I figure the 6.5 Grendel is a big enough cartridge that just about anything would work.

Anyone have any strong opinions?

I hand load.

90gr TNT, 100gr TTSX, Partition, 107gr TMK, 120gr Gold Dots?

Saw a gel shot on ar15.com of a 123gr SST from a 12" barrel that looked good.

This is a friendly ask please no hard feelings.

Thanks.