You might want to consider the Templar Fast Rail system. It allows ou to quickly change calibers without buying multiple uppers and rails.
It allows you to quickly change barrels from Grendel, Beowulf and 5.56 on the same upper. The barrel change takes about 3 minutes.
To go to 5.56, you also need to swap out the bolt, but that only takes a few minutes too.
The advantage is that you get to use the same, rail, scope, charging handle, carrier,iron sights, etc. You just print out a cheat sheet for each caliber of the scope settings for that caliber and use the same optics.
The system works by using an elongated barrel nut. The rail clamps to the barrel nut and is extremely strong.
You just have to be sure and use a gas block on each barrel that the rail can slide over. Any low profile block will do.
To take off the rail you loosen two allen screws and slide it off.
You just need the rail and a barrel nut for your existing barrel, then any new caliber barrel you get with the extended barrel nut.
You can buy the barrels from Templar too.
See:
http://templarcustom.com/products/railshandguards
RR