AR15performance...

[LightningII]

Hunting situations? Shot placement trumps all. Assuming adequate penetration and sufficient bullet mass to permanently disrupt a vital structure once it's hit, very minor differences in grain weight and frontal area are moot. (And, yes, the differences between 110gr and 120gr and 6.8 and 6.5 are, indeed, insignificant relative to the body mass of a whitetail deer.)

John

agreed on placement. always.
The high BC Grendel bullet SHOULD retain velocity a little better after it strikes, but I doubt that the animal knows the difference.